The study of amyloid structure and growth has been motivated by their implication in many human diseases. There are more than 20 diseases associated with excessive deposits of amyloid plaques in the affected tissue or organ including Alzheimer's disease (AD), Parkinson's disease (PD), type II diabetes, and spongiform encephalopathies. 

We are developing new approaches to single molecule measurements to enhance our ability to extract useful information from them. Innovations include data acquisition and instrument automation, incorporation of microfluidics, development of new labeling methods, and investigation of various immobilization schemes.