Michael J. Vitarelli, Jr. and David S. Talaga, Theoretical models for electrochemical impedance spectroscopy and local ζ-potential of unfolded proteins in nanopores. J. Chem. Phys. 139, 105101 (2013); http://dx.doi.org/10.1063/1.4819470 (8 pages)

Aleksey Vishnyakov, David S. Talaga, and Alexander V. Neimark, DPD Simulation of Protein Conformations: From α‐Helices to β‐Structures. J Phys Chem Lett 2012, 3, 3081-3087.

Vitarelli, M. J., Prakash, S. & Talaga, D. S. Determining nanocapillary geometry from electrochemical impedance spectroscopy using a variable topology network circuit model. Anal. Chem. 83, 533–541 (2011).

Li, J. & Talaga, D. S. The distribution of DNA translocation times in solid-state nanopores. J. Phys.-Cond. Matt. 22, – (2010).

“Chapter 6: Sensing Single Protein Molecules with Solid-state Nanopores" Bradley Ledden, Daniel Fologea, David S. Talaga, Jiali Li.Nanopores: Sensing and Fundamental Biological Interactions. Ed. Rashid Bashir and Samir Iqbal Springer, New York, NY (2011)

We are developing new approaches to single molecule measurements to enhance our ability to extract useful information from them. Innovations include data acquisition and instrument automation, incorporation of microfluidics, development of new labeling methods, and investigation of various immobilization schemes.

Talaga, D. S.; Li, J. Single-Molecule Protein Unfolding in Solid State Nanopores. J. AM. CHEM. SOC 2009, 131, 9287–9297.